Research Topic · Peer-Reviewed

Drug Development

Drug development is the structured progression of a candidate molecule from a validated lead through preclinical characterization, clinical evaluation, and manufacturing toward an approved therapeutic. It encompasses pharmacology, formulation, dose selection, assessment of efficacy and safety, characterization of dr…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 12× across the literature 🔖 ISSN 2326-0793

Overview

Drug development is the structured progression of a candidate molecule from a validated lead through preclinical characterization, clinical evaluation, and manufacturing toward an approved therapeutic. It encompasses pharmacology, formulation, dose selection, assessment of efficacy and safety, characterization of drug-drug interactions and adverse effects, and the regulatory and quality requirements that govern each stage. Early development relies on integrated in silico, in vitro, and in vivo investigation to define mechanism, exposure, and liability, while preclinical disease models, including in vitro systems for cardiotoxicity and safety testing and stem cell-derived cardiomyocyte assays, help predict clinical performance before human exposure. Toxicology and drug-safety evaluation are continuous priorities that determine whether a candidate advances. Structure-activity relationship analysis, illustrated by the historical development of agents such as the sulfonamides, underpins rational optimization, and proteomic and genomic techniques support target validation, biomarker discovery, and stratification for diagnostics and personalized therapy. Development is increasingly informed by individualized approaches that connect pharmacogenomics to tailored medication and nutrition, by antimicrobial stewardship considerations, and by accelerated programmes such as vaccine development under pandemic conditions. The journal publishes peer-reviewed research spanning these molecular, preclinical, translational, and safety dimensions of bringing new medicines from concept to clinical use.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Kenneth LundstromCorresponding author
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603

How this research is being cited

The 12 articles above have been cited 12 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Drug Development, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Proteomics and Genomics Research (ISSN 2326-0793).

Journal editorial board
Juan Sainz · Spain Bobbie-Jo M. Webb-Robertson · United States Feng Ding · China

This page summarises published research for orientation; it is not medical or professional advice.