Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing
articles matching p53 — open any to read the full text,
or download the PDF or XML.
Mar 2022 DOI 10.14302/issn.2572-3030.jcgb-22-4121
Pierre Diaga SARRCorresponding author
Laboratory of Clinical Cytology, Cytogenetics and Reproduction Biology, Aristide Le Dantec Hospital, Dakar-Senegal
Introduction Genomic mutations in TP53 gene in association with etiological risk factors have been associated with oral carcinogenesis. Herein, we screened for genomic variants of TP53 predisposing to oral cancers in Senegalese patients. Methodology 88 patients with confirmed diagnostic were recruit…
Dec 2018 DOI 10.14302/issn.2326-0793.jpgr-18-2422
Satyajit PatraCorresponding author
This review summarizes tumor development in p53‑deficient mouse models, discussing tissue specificity, cooperating pathways, and insights into human cancer biology.
Dec 2025 DOI 10.14302/issn.2997-2108.jcc-25-5657
Zahraa M EssamCorresponding author
Viral infections contribute to a significant proportion of human cancers, with human papillomavirus (HPV) being one of the most well-established oncogenic viruses. This review summarizes HPV biology, transmission, classification, molecular mechanisms of carcinogenesis, epidemiology of HPV-associated…
Jan 2019 DOI 10.14302/issn.2641-5526.jmid-18-2529
Juan Luis Fernández-MartínezCorresponding author
Discrimination of case-control status based on gene expression differences has potential to identify novel pathways relevant to neurodegenerative diseases including Parkinson’s disease (PD). In this paper we applied two different novel algorithms to predict dysregulated pathways of gene expression a…
Mar 2017 DOI 10.14302/issn.2326-0793.jpgr-17-1447
Timothy D. HowardCorresponding author
Factors that contribute to the onset of atherosclerosis may be elucidated by bioinformatic techniques applied to multiple sources of genomic and proteomic data. The results of genome wide association studies, such as the CardioGramPlusC4D study, expression data, such as that available from expressio…
Jan 2016 DOI 10.14302/issn.2574-4372.jesr-15-768
James E. TroskoCorresponding author
The human OCT4 gene encodes a transcription factor that maintains pluripotency and self-renewal in Embryonic Stem (ES) cells. This gene generates several known transcripts by alternative promoter and alternative splicing (OCT4A, OCT4B and OCT4B1). Even though OCT4A is the main isoform responsible fo…