Search results for “Model”

About 100 results in articles

Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching Model — open any to read the full text, or download the PDF or XML.

High-Throughput Complex Disease Modeling for Ethical Drug Discovery: Clinical Relevance of a NAM Platform for Cancer Biomarker Development

May 2026 DOI 10.14302/issn.2572-3030.jcgb-26-6307
Arne-C. FaisstCorresponding author

The development of tumor biomarkers derived from blood, or its components, has become pivotal in advancing early cancer diagnosis. Malignant transformations induce cancer-specific alterations in the transcriptome, proteome, and secretome of tumor cells. Recent studies highlighted similar alterations…

A New Model of Body Composition: Concept and Design Features of the DBA-Model

Apr 2026 DOI 10.14302/issn.2574-450X.jom-26-6138
Nicolaus DahlmannCorresponding author

Indices, based on data such as height and weight in general and in particularly the body mass index (BMI), are often used to assess overweight. However, there is limited capacity to differentiate the amount of fat mass between individuals. This review refers to an anthropometric model called Dahlman…

Diabetic Mouse Delayed Wound Model Following Treatment with the NerveStim™ Neuropathy System

Apr 2026 DOI 10.14302/issn.2640-6403.jtrr-26-6077
Margaret KalmetaCorresponding author

Delayed wound healing in diabetes is characterized by impaired angiogenesis, persistent inflammation, extracellular matrix dysregulation, and peripheral neuropathy. A preclinical study was conducted using a diabetic mouse delayed wound model to evaluate the surrounding tissue of a wound, (its periwo…

Mathematical Modelling of Typhoid Fever Transmission Dynamics and Intervention Impact in Harare, Zimbabwe (2018–2020)

Dec 2025 DOI 10.14302/issn.2643-2811.jmbr-25-5731
Innocent MukeredziCorresponding author

Background Typhoid fever remains a significant public health issue in Harare City, Zimbabwe, exacerbated by recurrent outbreaks between 2018 and 2020. Key challenges, including inadequate water supply and sanitation infrastructure, high population density, and limited healthcare access, have intensi…

The Energy–Matter–Behavioral Model of Mental Health Hygiene: A Systems-Based Framework for Sustainable Well-Being

Dec 2025 DOI 10.14302/issn.2474-9273.jbtm-25-5603
Mark ClarkCorresponding author

The Energy–Matter–Behavioral (EMB) model offers a systems-based lens for understanding and maintaining mental health hygiene. This framework integrates stress reduction, biological resilience, and behavioral reinforcement into a coherent triad, addressing not only symptoms but underlying energetic a…

Existential Therapy and the Contextual Model: Unified by Presence, Flexibility, and Meaning-Making

Nov 2025 DOI 10.14302/issn.2574-612X.ijpr-25-5771
Anthony CameronCorresponding author

This article offers a literature review and theoretical synthesis and application of existential therapy and the contextual model. It reviews the contextual factors that may be predictive of positive therapy outcomes in general, identifies distinct types of existential therapy, highlights core commo…

Learning and Memory in an Animal Model of Longevity: The Ames Dwarf Mice

Oct 2025 DOI 10.14302/issn.3070-2313.jeh-25-5757
David P. AustinCorresponding author

The Ames dwarf mice have a recessive mutation of the PROP-1 gene that produces hereditary dwarfism. The abnormality is responsible for an anterior-pituitary deficiency that results in a substantial reduction of growth hormone, thyroid-stimulating hormone, and prolactin. These mice are smaller in siz…

A New Model of Body Composition Detects Association Between Severe Obesity and Increase in Skeletal Muscle Mass

Sep 2025 DOI 10.14302/issn.2643-2811.jmbr-25-5688
Nicolaus DahlmannCorresponding author

Obesity is associated with functional limitations in muscle performance. The true effect of obesity on skeletal muscle mass, including any interactions with aging effects, remains to be elucidated. The present study investigated the impact of obesity on the stimulation of muscle growth, based on a n…

Loneliness and Bedtime Procrastination: Exploring a Model of Interconnectedness Among Young Adults in Germany

Oct 2024 DOI 10.14302/issn.2574-4518.jsdr-24-5287
Michael HastCorresponding author

Background/Aim This study aimed to examine the relationship between loneliness and bedtime procrastination in young adults in Germany, offering critical insights into the development and maintenance of both conditions. Specifically, it sought to test a new model that connects these two psychological…

Parents and Siblings as Role Models in Dealing With Digital Screen Media. Findings from A Media Fasting Intervention

Jun 2024 DOI 10.14302/issn.2381-862X.jwrh-24-5099
Silke SchwarzCorresponding author

Parents' and siblings’ role model motivation and function could play an important role in positively influencing both their own media behavior and that of family members. To investigate whether parents and siblings consciously take on this role model function, their intentions were being evaluated w…

Ontogenes in Drosophila Melanogaster and a Model of Speciation

Mar 2024 DOI 10.14302/issn.2689-4602.jes-24-4956
B.F. ChadovCorresponding author

A new type of mutations-dominant lethals with a facultative manifestation -were discovered in D. melanogaster in 2000. These mutations were named conditional mutations. Under restrictive genetic conditions, the mutations manifest themselves as dominant lethals, whereas dominant lethality disappears…

Evaluating the Effectiveness of Quality Improvement Strategies in Mid-Level Private Healthcare Facilities of Lagos State: A Donabedian Model-Based Approach

Feb 2024 DOI 10.14302/issn.2641-4538.jphi-23-4871
Nnenna Mba-OduwusiCorresponding author

Background This study evaluates the effectiveness of quality improvement (QI) strategies in mid-level private healthcare facilities in Lagos State, with a focus on the structural components, healthcare processes, and healthcare outcomes. Employing the Donabedian model, the research aims to comprehen…

Journal of Enzymes Open Access

Enzyme Immobilization on Polypropylene Film: A Role Model for Biocatalytic Polymer Membranes?

Dec 2023 DOI 10.14302/issn.2690-4829.jen-23-4799
Patrizia GartnerCorresponding author

Polymer electrolyte membrane (PEM) technologies hold promise for sustainable energy solutions, yet pinhole-related challenges persist. Our research introduces a novel biohybrid approach to self-healing, enhancing multiple healing cycles with minimal membrane disruption. Initial steps involve immobil…

Osteoarthritis and Depression Update: 2023-Can the Stress and Coping Model Help?

Aug 2023 DOI 10.14302/issn.2474-7785.jarh-23-4730
Ray MarksCorresponding author

Background Osteoarthritis and depression are both key barriers to healthy aging and greatly heighten the risk for many negative health issues that seriously impact life quality. When combined what are the implications? Aim This mini review examines 2023 data pertaining to osteoarthritis and depressi…

A General Approach to Modeling Covid-19

Jul 2023 DOI 10.14302/issn.2643-2811.jmbr-23-4556
Raul IseaCorresponding author

The present work shows that it is possible to analytically solve a general model to explain the transmission dynamics of SARS-CoV-2. First, the within-host model is described, and later a between-host model, where the coupling between them is the viral load of SARS-CoV-2. The within-host model descr…

Baroreflex Sensitivity, Cardiac and Kidney Remodeling and Deterioration in Vasoactive Substances Content in Blood in Experimental Model of Renovascular Hypertension. Action of Natural Flavone, Luteolin

May 2023 DOI 10.14302/issn.2574-4488.jna-23-4545
N.A. PapiashviliCorresponding author

This study aimed to analyze pharmacological actions of phenolic compound luteolin on the renal and cardiac hypertrophy, blood pressure (BP), baroreflex sensitivity (BRS), levels of epoxyeicosatrienoic acids (EETs), prostaglandin E-2 (PGE-2) and endothelin-1 (E1) in plasma in the 2 kidney - 1 clip (2…

Time Series Analysis and Prediction of COVID-19 pandemic using Dynamic Harmonic Regression Models

Apr 2023 DOI 10.14302/issn.2643-2811.jmbr-23-4528
Lei WangCorresponding author

Rapidly spreading Covid-19 virus and its variants, especially in metropoli- tan areas around the world, became a major health public concern. The tendency of Covid-19 pandemic and statistical modelling represent an urgent challenge in the United States for which there are few solutions. In this pape…

Seasonal ARIMA model for Covid-19 pandemic Prediction in the United States

Apr 2023 DOI 10.14302/issn.2643-2811.jmbr-23-4529
Lei WangCorresponding author

The COVID-19 pandemic has had a profound impact on global health and economies. The pandemic continues to spread and accurate forecasting of its spread is essential for the effective management of healthcare systems and the development of effective policies. The development of forecasting models for…

Experimental Study by the Plan Composite Centered Method, Modeling and Optimization of Hydrogen Production by Alkaline Electrolysis

Apr 2023 DOI 10.14302/issn.2377-2549.jndc-23-4494
Zina MeddebCorresponding author

A planned experimental study on the production of green hydrogen by alkaline electrolysis is carried out by the Plan Composite Centered (PCC) method. The parameters studied are the concentration of the electrolyte, the distance between electrodes, the height of the electrodes, the total supply volta…

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